SCIENCE FORMULA
ICON DNA: Microbiome Science Formula™ for Immunity, Digestion and Long-Term Support
ICON DNA’s Microbiome Science Formula™ is the result of several years of research and development in collaboration with Latvia University Scientists.
Bringing together expertise in microbiome science, biochemistry, and mycology, this advanced formula was designed to support gut–immune interaction, digestive equilibrium, and long-term physiological resilience through the natural intelligence of mushrooms.
At ICON DNA, we understand that periods of immune vulnerability — whether due to seasonal shifts, environmental exposure, or personal health transitions — call for intentional, science-driven nutritional support. Our formula was designed with this need in mind.
Centred Around mushroom Beta-Glucans and Natural Vitamin D₂
ICON DNA is formulated with two key compounds derived from our own climate-controlled cultivation of Pleurotus eryngii mushrooms in Northern Europe:
Beta-glucans, scientifically studied for their ability to support the normal function of the immune system, encourage gut microbial balance, and promote short-chain fatty acid (SCFA) production
Natural Vitamin D₂ (ergocalciferol), whose concentration is enhanced through a scientifically developed and studied method — designed to increase D₂ levels in a way that preserves the natural integrity of the mushroom and its nutrients
This formulation contributes to the maintenance of normal immune function, muscle, and bone health, as recognised by the European Food Safety Authority (EFSA).
Nutritional Support in Times of Immune Imbalance
Scientific literature has explored the role of beta-glucans in supporting immune function following intensive therapies, as well as their contribution to rebalancing gut microbiota under stress.
While ICON DNA is not a medical product and does not treat or cure any condition, it is formulated to support the normal function of the immune system, which may be particularly relevant during or after periods of physiological challenge or immune system disruption.
Long-Term Daily Use for Wellness Maintenance
ICON DNA is well-suited for gentle, long-term daily use as part of a proactive wellness routine.
Ongoing research suggests that consistent dietary intake of mushroom beta-glucans and Vitamin D₂ may help maintain key physiological functions related to immunity, digestion, and inner resilience — especially when paired with a balanced lifestyle.
This makes ICON DNA a meaningful daily addition for those who value preventive self-care and sustained balance.
Disclaimer
ICON DNA is a food supplement. It is not intended to diagnose, treat, cure, or prevent any disease. The statements on this page have not been evaluated by the U.S. Food and Drug Administration.
EFSA-permitted health claims on Vitamin D₂ include: “contributes to the normal function of the immune system.”
Claims related to beta-glucans reflect current scientific literature and are presented in accordance with EU Regulation (EC) No 1924/2006.
Scientific Evidence Reference List
IMMUNE FUNCTION SUPPORT
Kyriacou A. et al. (2020)
Effects of Rich in β-Glucans Edible Mushrooms on Aging Gut Microbiota Characteristics: An In Vitro Study.
Molecules 2020, 25(12), 2806.
→ Found that Pleurotus eryngii and P. ostreatus increased beneficial gut bacteria and SCFA production, both of which are involved in immune modulation.
[DOI: 10.3390/molecules25122806]Effects_of_Rich_in__Glu…Vetvicka V. et al. (2007)
Beta-glucan – natural immunomodulator.
Clinical Immunology, 2007.
→ Reviewed immunological effects of beta-glucans, including macrophage activation and modulation of innate immunity.EFSA Panel on Dietetic Products, Nutrition and Allergies (2009)
“Vitamin D contributes to the normal function of the immune system.”
EFSA Journal 2009; 7(9):1229.
→ Authorised EU health claim for Vitamin D₂.
[EFSA Reference: ID 280]
GUT MICROBIOME & PREBIOTIC EFFECTS
Kyriacou A. et al. (2020)
→ Demonstrated that P. eryngii had a lactogenic effect, increasing Lactobacillus populations in elderly fecal samples after 24-hour fermentationEffects_of_Rich_in__Glu…Mitsou E.K. et al. (2019)
Prebiotic potential of mushroom-derived polysaccharides: modulation of microbiota and fermentation byproducts.
→ Supported SCFA production (especially butyrate), crucial for gut and immune health.
CELLULAR & METABOLIC SUPPORT
Gil-Ramírez A. et al. (2011)
Edible mushrooms as potential sources of new hypocholesterolemic compounds.
Proceedings of ICMBMP7
→ Demonstrated that mushroom beta-glucans and phytosterol-like compounds may reduce cholesterol absorption and support lipid metabolism.
Edible_mushrooms_as_pot…Rop O. et al. (2009)
Beta-glucans in higher fungi and their health effects.
Nutrition Reviews, 2009.
→ Review of beta-glucans’ antioxidant, cholesterol-lowering, and metabolic-modulating properties.
VITAMIN D₂ FROM MUSHROOMS
Teichmann A. et al. (2007)
Sterol and vitamin D₂ concentrations in cultivated and wild-grown mushrooms: Effects of UV irradiation.
Journal of Agricultural and Food Chemistry.
→ Confirmed that Pleurotus species exposed to UV light naturally convert ergosterol into Vitamin D₂.Cardwell G. et al. (2018)
Mushroom consumption and vitamin D status in Europe: A narrative review.
Nutrients 2018, 10(10), 1498
→ Highlights mushrooms as a natural, non-animal source of Vitamin D₂ with bioactive potential when UV-treated.
